https://bugs.winehq.org/show_bug.cgi?id=42061
--- Comment #2 from Michael Müller michael@fds-team.de --- Could you describe your setup a bit more? Are you using NVIDIA TwinView? Do you run DOOM in OpenGL or Vulkan mode?
I think I had the same issue with games when I used NVIDIA TwinView. If I remember correctly the NVIDIA driver emulates a single CRT in TwinView mode and changing the resolution therefore affects both monitors. If DOOM changes the resolution to 1920x1080, it basically disables your second monitor. I would suggest to arrange the displays using xrandr without TwinView. This should fix those quirks.