http://bugs.winehq.org/show_bug.cgi?id=35599
--- Comment #1 from Nikolay Sivov bunglehead@gmail.com --- Yes, it's a known thing. The reason it doesn't work is quite obvious, 'runtest' does this to run a test program:
--- exec $WINETEST_WRAPPER "$topobjdir/wine" "$program" "$@" ---
and fails to find 'wine', cause it's not created for 64bit build dir. I had this problem a couple of weeks ago when I first tried to run some test on 64 bit, all you need is to create 'wine' symlink with the same target as 'wine64'. After that usual 'make test' works and you can use 64bitpath/wine to start wine if you like.