http://bugs.winehq.org/show_bug.cgi?id=31113
--- Comment #128 from Steven V. Wilson funmaker_11@yahoo.com --- I disabled the Stam overlay about a year ago and the game has not crashed once in all that time.
Solution
Gointo your Steam liabray and right click on Civilization 5 Select options On the main tab -should come up by default- deselect the use overlay check box click ok
click on the play button and enjoy. Problem solved.
Now we just need the wine devs to fix the wine compatablitie with the Steam overlay as this fix works for every single game I have played via wine.