https://bugs.winehq.org/show_bug.cgi?id=41695
--- Comment #9 from yumekuineru@hotmail.com --- (In reply to sylviu44 from comment #7)
The vcrun2015 overrides are the issue. In a clean 32bit prefix, run winetricks to install vcrun2013 and d3dx9. Then add a (native, builtin) override for msvcp140 from winecfg. Running LeagueClient.exe --no-sandbox using the patched wine should now work.
This worked for me, thanks.
win64 prefix, 1.9.22 with CSMT enabled, uninstalled vcrun2015 with winetricks, still have vcrun2013 and (I think) d3dx9_39 installed. Removed all overrides, and added the single override msvcp140
I am also using the old patch in comment 1 (I think it was to fix the store?), as well as new newer nearbyint-patch.