https://bugs.winehq.org/show_bug.cgi?id=45732
--- Comment #10 from Scott Serbousek airetamstrm@gmail.com --- I was able to play the game up to the final part of the game using a couple methods:
-Mark your map with a waypoint then use shift to "auto drive". Limitations are that you can't really turn the vehicle around reliably this way, and this does not work off-road.
-Map your map with a waypoint and have your companion character drive. Unlike autodrive, they'll turn the vehicle around. I was able to use this throughout the late game to make it all the way to the end compound.
-Use a helicopter. Park one close to the mission area so that you can use it to chase/flee.
The game cannot be finished as is because the game requires you manually drive through an area near the ending and you cannot turn. You cannot leave the vehicle for mission reasons and thus your partner cannot drive either, leaving you stuck against a wall you cannot get around.
I was not able to get joysticks working in WINE with this game. I even used some elaborate Steam workarounds to attempt a fix, to no avail. If someone can figure this out, it is a possible workaround to finish the game.
As said, only land (and water too, confirmed) vehicles are affected this way.