http://bugs.winehq.org/show_bug.cgi?id=24892
--- Comment #1 from cedric.dewijs@telfort.nl 2010-10-25 13:23:25 CDT --- Found this thread here: http://ubuntuforums.org/showthread.php?t=602641 Open up a console and type 'regedit'. Then go to HKEY_current_user > software > wine > X11 driver
Right click in the white area and select "New > String Value". Type in "UseXRandR" without the quotes and hit enter. Then double click what you just made and type 'N'. Quit regedit and start your game up. It should work in full screen.
I added the registry value, and resetted my screens by re-applying the settings in Nvidia Xserver settings. Unfortunately the results are the same as the above post.