https://bugs.winehq.org/show_bug.cgi?id=41153
--- Comment #3 from Ken Thomases ken@codeweavers.com --- (In reply to Jurjen from comment #2)
Thanks for getting back so quickly. In the flicker, the image of the load-screen of the game is still visible, so it did happen after playing it. Perhaps this gives some more info?
Even after the reboots? Try shutting the Macbook down entirely and waiting 15 seconds before starting it up again.
Anyway, the flicker would presumably be showing you some leftover data in the VRAM. The precise nature of that data is not really significant.