https://bugs.winehq.org/show_bug.cgi?id=42856
--- Comment #14 from Hugo "ThePooN" Denizart thepoon@cartooncraft.fr --- I am running a fairly tuned Wine install (as described in my blog post, although it has changed a bit) and have not tried vanilla Wine in recent times.
@Ivan With pipewire, you should use PIPEWIRE_LATENCY. Beware that it conflicts with PULSE_LATENCY_MSEC and these two should not be used together.