http://bugs.winehq.org/show_bug.cgi?id=8336
--- Comment #42 from John P Sims jsims2359@gmail.com 2009-09-22 15:42:29 --- (In reply to comment #41)
For me it still does not work, for I'am using the retail version, which will not install properly and for getting the game started you need to use winetricks. Anyway it does not let you log in you profile (while you WILL be able to connect to Relic Online)
I'll get the steamversion soon, then we'll see whether it is ony a problem of my OS or more general.
Do a git compile and try again with a clean wine prefix. No need to spend your money if it can be avoided.