http://bugs.winehq.org/show_bug.cgi?id=3037
--- Comment #59 from Andrew Gaydenko a@gaydenko.com 2010-06-22 12:28:00 --- André, thanks for tip!
I have installed 1.2~rc4-0ubuntu1~lucidppa1 version - with the same behaviour. I hope I will not discover any show stoppers in RCs, so I'll keep ppa source during upcoming future.
As for .tran file - LTspice uses .asc files for schematics. The issue doesn't depend on opened file (just "New" is sufficient).