http://bugs.winehq.org/show_bug.cgi?id=6297
--- Comment #36 from Luke Bratch l_bratch@yahoo.co.uk 2008-03-05 11:07:58 --- (In reply to comment #29)
Something to try would be to dumping your caches as described at http://linux-mm.org/Drop_Caches i.e. run "sync; echo 3 > /proc/sys/vm/drop_caches"
I came here to report this myself but see that it's already been suggested. Since I use ReiserFS I cannot use the chattr trick, however running "echo 3 > /proc/sys/vm/drop_caches" just before launching troublesome games has worked every time so far.