http://bugs.winehq.org/show_bug.cgi?id=36546
--- Comment #2 from Artem S. Tashkinov t.artem@mailcity.com --- (In reply to Bruno Jesus from comment #1)
I do that too but I don't think I've ever hit this issue. Is there a small program that can trigger it?
The most recent example is Futuremark SystemInfo which refuses to install on tmpfs'ed .wine prefix:
http://www.futuremark.com/support/systeminfo
Many other applications bundled as MSI installers have this problem.