http://bugs.winehq.org/show_bug.cgi?id=35525
--- Comment #2 from Maurizio Oliveri 6tsukiyami9@gmail.com --- The screenshot isn't taken from the game, but via Steam overlay, which means it somehow gets the wrong input from the game's window, or messes it up.
Sorry, I realize I kinda forgot to add more info... To try it out: launch the native Steam client for Linux, add a non-Steam game and then add a game launched via Wine. The overlay works fine, but screenshots appear upside-down, so Wine and Steam, somehow, aren't communicating that well, messing up screen informations