http://bugs.winehq.org/show_bug.cgi?id=12273
--- Comment #5 from Lei Zhang thestig@google.com 2008-04-01 17:51:11 --- Can you try explicitly specifying the SWCursor option for the fglrx driver config?
Option "SWCursor" "on"
Try with both the setting on and off and see if it makes a difference.