http://bugs.winehq.org/show_bug.cgi?id=12360
--- Comment #2 from Austin English austinenglish@gmail.com 2008-04-07 12:52:32 --- skynet@debian:~$ wine '/home/skynet/.wine/drive_c/Program Files/Neo_Mule_v4.50_bin/emule.exe'
Don't run programs like this, cd to the directory first.
Can you run a regression test: http://wiki.winehq.org/RegressionTesting