http://bugs.winehq.org/show_bug.cgi?id=15091
--- Comment #8 from Dmitriy Geels dmitriy.geels@gmail.com 2009-03-31 01:01:04 --- Problem is still there in 1.1.18.
I think, I found the solution: http://wiki.jswindle.com/index.php/Wine_Registry#Serial_Com_Port
There is no keys under HARDWARE\DEVICEMAP\SERIALCOMM, so this should be the problem.