http://bugs.winehq.org/show_bug.cgi?id=20181
--- Comment #26 from Roderick Colenbrander thunderbird2k@gmail.com 2009-11-17 12:43:51 --- You should install a 32-bit glxinfo and once that says direct rendering is enabled try Wine again. I have no experience with gentoo, so you have to ask on their forums or in their irc channel.