http://bugs.winehq.org/show_bug.cgi?id=23487
--- Comment #2 from GyB gyebro69@gmail.com 2012-02-25 01:04:45 CST --- Still present in Wine-1.4-rc5.
When changing screen resolution in full-screen mode, the game becomes unresponsive (music keeps playing and mouse pointer changes back to the default X Window pointer). There's no way to interact with the game from that point on. This doesn't happen when the game is running in windowed mode.
Nvidia 250 / driver 290.10