https://bugs.winehq.org/show_bug.cgi?id=47198
--- Comment #59 from Andrew Wesie awesie@gmail.com --- (In reply to mail+wine from comment #58)
Do I really need a 32 bit kernel or is there some other way to build Wine so that LoL thinks it runs on a 32 bit only system?
The detection of WoW64 is based on the %cs register. The default value of the cs segment selector is determined by the kernel, not user space, hence you need to have a 32-bit kernel if you want to run without any of these patches.