https://bugs.winehq.org/show_bug.cgi?id=39291
--- Comment #5 from Ken Thomases ken@codeweavers.com --- Thanks for those logs.
Are you using an Asian input method (e.g. Pinyin, Hiragana, etc.)? Your keystrokes are being routed through imm32 and being sent for processing through an input method. I'm not sure if this is something the game could be doing explicitly or if it's because the Mac driver thinks you're using an input method.
If you're not using an input method, do you have any third-party software for intercepting keys and doing something with them? It might be acting as an input method or some other kind of non-keyboard-layout input source.
If you can disable any input method or other such software and test, the problem might go away. See System Preferences > Keyboard > Input Sources and/or the Input menu in the menu bar.
Otherwise, can you collect a +tid,+key,+keyboard,+imm log?