http://bugs.winehq.org/show_bug.cgi?id=25922
--- Comment #3 from Jan Hoogenraad jan-winehq@h-i-s.nl 2011-01-29 16:11:17 CST --- Hotfile.exe, which is a separate program to sync. I found out that I could reset this by de-coupling the USB port from the computer. After that, hotsync ran fine on wine-1.2.2.
Apparently, the usbserial can get into a mode that triggers the fixme.