https://bugs.winehq.org/show_bug.cgi?id=42061
--- Comment #3 from C0rn3j spleefer90@gmail.com --- (In reply to Michael Müller from comment #2)
Could you describe your setup a bit more? Are you using NVIDIA TwinView? Do you run DOOM in OpenGL or Vulkan mode?
I think I had the same issue with games when I used NVIDIA TwinView. If I remember correctly the NVIDIA driver emulates a single CRT in TwinView mode and changing the resolution therefore affects both monitors. If DOOM changes the resolution to 1920x1080, it basically disables your second monitor. I would suggest to arrange the displays using xrandr without TwinView. This should fix those quirks.
I've never heard of Nvidia TwinView and I can't find it in nvidia-settings either.
I've had problems with a lot of games launching on the wrong monitor, even outside of WINE. some work fine, some don't, but DOOM on WINE just straight out takes the secondary screen with it.(as in turns it off)