http://bugs.winehq.org/show_bug.cgi?id=30947
--- Comment #3 from Vincent Povirk madewokherd@gmail.com 2012-06-19 20:59:18 CDT --- Can you get a +module,+loaddll,+mscoree log of the failure?
I see there's a demo at http://download.cnet.com/Tropico-4-Demo/3000-2119_4-75547516.html, just making a note of it in case it shows the same problem.