http://bugs.winehq.org/show_bug.cgi?id=27573
--- Comment #4 from Aric Stewart aric@codeweavers.com 2011-06-23 07:41:47 CDT --- I am not convinced it is a uniscribe issue. Did you have it working in the past?
maybe you could do a git bisect to find when it started failing.
the Indic shaping started going in after Release 1.3.20. so you could try it there to see if it works there or not.
-aric