https://bugs.winehq.org/show_bug.cgi?id=56087
--- Comment #9 from Rafał Mużyło galtgendo@o2.pl --- fuseiso doesn't give you a drive, just access to the filesystem.
For a drive (if it actually explicitly needs a *cdrom* drive), you'd need something like cdemu (even though I find the stronger ties with systemd in the more recent versions, it still works without it, you just need to run the daemon manually).