https://bugs.winehq.org/show_bug.cgi?id=46624
--- Comment #35 from Zel Uneec zculek@gmail.com --- I have this issue as well on Mint 20.3 (Cinnamon) with RX 460 2GB VRAM - Real Time Lighting greyed out and graphics blurry when compared to e.g. Debian with nVidia card or Windows 10 with the same (RX 460) card. The "blurry" thing is probably what Tom B already mentioned:
In addition the game sets the remaster resolution to 1080p (or less, I can't really tell) rather than the 4k graphics.
I've tried both opensource and proprietary AMD drivers, got same behavior.