http://bugs.winehq.org/show_bug.cgi?id=29844
--- Comment #41 from zoroaster zoroaster@inode.at 2012-04-28 09:17:49 CDT --- (In reply to comment #40)
Then wine is probably using the absolute axis rather than the relative axis.
Run 'xinput --test-xi2' or even 'xinput --test 6' from a terminal, and move the mouse past the screen and you should see the relative motion still being sent.
Verified. XI2 works correctly and fully supports relative movement without restrictions now.
The noticed behavior must be an issue in connection with Wine.