http://bugs.winehq.org/show_bug.cgi?id=29079
--- Comment #4 from Brandon Howard FinalCrisisSX@Hotmail.com 2011-11-18 16:57:59 CST --- Sort of good news! I tested Serious Sam HD: The First Encounter, and the lag shows up there too. It is more constant than in TSE for whatever reason.
The good news is, a playable demo is here that would probably have the same issue as the retail: http://store.steampowered.com/app/41000/