http://bugs.winehq.org/show_bug.cgi?id=20296
--- Comment #23 from Christoph Hohmann reboot@gmx.ch 2010-01-28 16:12:33 --- As a software developer I would suggest that not every issue why LoL does not run is added to this bug. It is about the crash of the launcher, which is caused by an unimplemented Windows API in Wine as shown with the small hack. Other issues should probably be discussed in the AppDB entry for LoL or added as other bugs.
For your information, with the information and patch on this bug it is possible to run the launcher, patch the client, start the PVP.net client and with Wine 1.1.37 and the last LoL patch it is even possible to login, but if you try to start a game the real game client crashes due to an unimplemented DirectX API.