http://bugs.winehq.org/show_bug.cgi?id=17988
--- Comment #5 from Vitaliy Margolen vitaliy@kievinfo.com 2009-04-09 20:40:49 --- All libraries have executable code. If reinforced no code can be executed from libraries that came from system mounted with noexec.
It's of course more complicated then that but it's all outside of what Wine can do. If you want to run a program under Wine no part of it can reside on a mount mounted with noexec option.