http://bugs.winehq.org/show_bug.cgi?id=21470
--- Comment #2 from Wiebe Cazemier wiebe@halfgaar.net 2010-01-24 15:25:22 --- Sorry, I forgot to include that.
GeForce 8400 GS nvidia-drivers 169.09-r1 Xorg: 7.2
I had this problem with a GeForce 6600 LE as well. Don't remember which drivers.
But as I said, it's also in the GDI renderer, it just shows differently. In OpenGL the mouse has a quarter of a second or so lag. In GDI, it's just a lower framerate.