http://bugs.winehq.org/show_bug.cgi?id=12592
--- Comment #17 from Matthew Croall phoozle@bigbighuge.com 2009-04-17 02:33:57 --- I experience this problem when I tunnel PhotoshopCS2 using X11 over ssh while being logged in via GDM as well.
E.G. Physical GDM login and SSH network login with the same user at the same time. Only 1 user running Photoshop but both running other Wine apps.
A system reboot or "wineboot -r" seems to fix it temporarily until I do a multi user login again.
I now make sure I log out when performing an application tunnel.