https://bugs.winehq.org/show_bug.cgi?id=38313
--- Comment #22 from Andrew Eikum aeikum@codeweavers.com --- Like I mentioned on that duplicate bug, I think this is a bug due to winecfg's failing to update the 32-bit registry with your changes. So 32-bit programs like Skyrim continue to use the old config (5.1 Surround) even though you set it to Stereo in winecfg.
I'll work on a fix, no need for more logs in the meantime.