https://bugs.winehq.org/show_bug.cgi?id=40613
--- Comment #42 from Eivind Eide xenofil@gmail.com --- (In reply to Zebediah Figura from comment #40)
If your prefix was created with upstream wine or with an older version of wine-staging, you'll need to modify the registry manually. Open regedit.exe, find the key HKEY_LOCAL_MACHINE\Software\Microsoft\Windows\CurrentVersion\Policies\System, and change the value of EnableLUA from 0 to 1.
Thanks! That's it.