http://bugs.winehq.org/show_bug.cgi?id=27225
--- Comment #8 from mitterco@hotmail.com 2011-06-16 17:24:02 CDT --- Still seeing glitchy mouse movements in games like Unreal and Serious Sam with 1.3.22. Not as bad as previous versions (especially 1.3.20) but it still exists.
Reverting to 1.3.19 or the stable 1.2.x releases fixes the problem.