http://bugs.winehq.org/show_bug.cgi?id=5347
--- Comment #31 from Mikolaj Zalewski mikolaj.zalewski@gmail.com 2007-10-10 19:31:02 --- In what version of Photoshop do you have problem with Save for Web?
As for the Alt key moving the window this is a known problem of the window manager - it doesn't pass such events to Wine but moves the window. You can either disable this feature somewhere in the desktop configuration or use Shift+Alt+Left click (this at least works for the Clone Stamp Tool)