http://bugs.winehq.org/show_bug.cgi?id=3952
--- Comment #22 from Sileon sileon@gmail.com 2007-12-16 21:23:59 --- If I have understood it correctly, it is not possible to support GameGuard in wine, atleast not the current GameGuard version, because of some protection techiques used.
See Anastasius Focht's comments in bug 7923 for more info.