https://bugs.winehq.org/show_bug.cgi?id=54800
--- Comment #6 from Austin English austinenglish@gmail.com --- (In reply to flyingwaffle from comment #5)
(In reply to Austin English from comment #3)
Not a blocker.
6.0.3 is very outdated, please retest in 8.x and if still present, attach the full terminal output.
I will note that as far as I know, League of Legends only works when using various patches on top of Wine. So, most people will be running a custom Wine 7.0 build from Glorious Eggroll: https://github.com/GloriousEggroll/wine-ge-custom/tree/7.0-GE-LoL
If using a custom build, bugs should be reported there.