[Bug 9527] Silent Hill 4 Does not start

http://bugs.winehq.org/show_bug.cgi?id=9527

--- Comment #1 from killertux   2007-08-30 16:30:53 ---
"Warning: the specified System directory L"c:\windows\system32" is not
accessible."

That line indicates ~/.wine corrupted in some way... incorrect permissions...
you have likely run this on root.

Anyway try with clean and fresh ~/.wine