https://bugs.winehq.org/show_bug.cgi?id=47764
--- Comment #6 from Sveinar Søpler cybermax@dexter.no --- (In reply to Jan from comment #5)
This bug is back in Wine 4.18, 4.19 and 4.20 (staging).
Yes. But have you tested to enable the option "Automatically capture the mouse in full-screen windows" in winecfg/Graphics ?
Atleast doing that seems to fix it for me.