http://bugs.winehq.org/show_bug.cgi?id=28898
--- Comment #55 from lyon@pvfree.net 2012-03-23 07:41:59 CDT --- (In reply to comment #54)
Ok, I just realised something really odd (which also explains my slow-downs). Somehow, two copies of Diablo III.exe get launched. As in, two distinct copies of the game.
This is a known bug in launcher: http://us.battle.net/d3/en/forum/topic/4254455412#12
I'll try your new patch later. I'm on a 64-bit machine right now and I'd need to recompile after installing 32-bit libs first.