https://bugs.winehq.org/show_bug.cgi?id=57557
--- Comment #9 from Jactry Zeng jactry92@gmail.com --- I tested Synthesia 9.8[1] on Wine 9.0 and 10.0rc3. Both work well; I can install it and start it.
It is possibly an issue of our environment instead of a Wine bug. You can only run 64-bit programs with a 64-bit Wine.
[1] https://cdn.synthesia.app/files/Synthesia-10.9-installer.exe