http://bugs.winehq.org/show_bug.cgi?id=12416
--- Comment #18 from Tom Stellard tstellar@gmail.com 2008-04-12 20:48:58 --- I just tested civilization 4 again after applying the 2nd patch posted by Stefan: http://www.winehq.org/pipermail/wine-patches/2008-April/053179.html
and now civilization 4 starts fine. It looks like this patch fixes the bug.