http://bugs.winehq.org/show_bug.cgi?id=11047
--- Comment #1 from Lei Zhang thestig@google.com 2008-01-06 02:29:03 --- Please don't run Wine as root, use a clean .wine directory, and run Wine as follows:
cd /mnt/cd wine setup.exe
You may want to consult the FAQ: http://wiki.winehq.org/FAQ