http://bugs.winehq.org/show_bug.cgi?id=13358
--- Comment #4 from Austin English austinenglish@gmail.com 2008-05-22 16:41:37 --- (In reply to comment #3)
no. i cannot restart X with ctrl+alt+bksp. i also cannot switch to a standard tty--mouse is locked, keyboard is locked.
the hardware is an HP Compaq dx5150 with integrated ATI Radeon Xpress 200
xorg-x11-server-Xorg-1.4.99.901-29.20080415.fc9.x86_64 xorg-x11-drv-ati-6.8.0-14.fc9.x86_64
Probably an ATI driver bug. File a bug with Fedora. You might try using vesa/vga driver as a workaround...