http://bugs.winehq.org/show_bug.cgi?id=22805
--- Comment #5 from Paul Vriens Paul.Vriens.Wine@gmail.com 2010-05-21 10:36:21 --- I'm running a wow64 setup. NetFx64.exe is a 32bit installer. install.exe is 64bit.
If I run /wine/wine64/wine install.exe on a clean .wine the installation starts (but fails due to some other bug). Could that be a hint?