https://bugs.winehq.org/show_bug.cgi?id=24392
--- Comment #20 from Béla Gyebrószki gyebro69@gmail.com --- (In reply to Matteo Bruni from comment #19)
Created attachment 51507 [details] Hack
The slowdown with motion blur is likely to be the same issue as bug 27879, I remember that the RGBA16-enabling patch was specifically added for Mass Effect 2 (bug 22548). Also I just recalled bug 30256 which is again around the same basic limitation, where you mention that Nouveau didn't suffer from the bug (I had the feeling you already tested it).
Does the attached (untested) patch workaround the issue? It's an updated version of attachment 38991 [details] from bug 27879.
The patch does not fix the problem in Mass Effect 1 & 2, nor it helps with bug #30256.