http://bugs.winehq.org/show_bug.cgi?id=21165
--- Comment #30 from Erich Hoover ehoover@mines.edu 2010-02-24 10:08:03 --- (In reply to comment #29)
... Could it be that you'd installed some kernel or driver update before the reboot? 195.22 driver here.
Entirely possible, I'm running the 185.18.36 driver - I don't believe Ubuntu ships any newer versions for Karmic.