[Bug 49176] New: Esync stopped working for multiple games in staging (applications crash on start)

[WineHQ Bugzilla]

https://bugs.winehq.org/show_bug.cgi?id=49176

Bug ID: 49176
           Summary: Esync stopped working for multiple games in staging
                    (applications crash on start)
           Product: Wine-staging
           Version: 5.8
          Hardware: x86
               URL: https://www.fileplanet.com/archive/p-28841/Evil-Genius
                    -Demo
                OS: Linux
            Status: NEW
          Keywords: download, regression
          Severity: normal
          Priority: P2
         Component: -unknown
          Assignee: [e-mail]
          Reporter: [e-mail]
                CC: [e-mail], [e-mail]
      Distribution: ---

Created attachment 67193
  --> https://bugs.winehq.org/attachment.cgi?id=67193
terminal output

Several games crash on start in Wine-Staging git version with errors like
these:
> > eventfd: Too many open files
> > 0024:err:winediag:FILE_CreateFile Too many open files, ulimit -n probably needs to be increased

I have the following values set in both /etc/systemd/user.conf and
/etc/systemd/system.conf:
DefaultLimitNOFILE=1024:1048576

The last good Staging commit when esync worked for those game:
https://github.com/wine-staging/wine-staging/commit/e30e2251253d1b856d62202c...

You can reproduce the problem with Evil Genius demo.

evilgenius_demo_en.exe  (195M)
md5sum: 58e4ea2c32dd981be4c02e579775aa43

wine-5.8-173-g9e26bc81165 (Staging)