http://bugs.winehq.org/show_bug.cgi?id=16456
--- Comment #43 from Rico kgbricola@web.de 2009-03-25 04:53:10 --- For users (e.g. Jeffrey Bonggren and I guess thefirstkeet@gmail.com, too), with x86_64 + nvidia (G80+) + something more than 3GB ram, please have a look here: http://www.nvnews.net/vbulletin/showthread.php?t=127984 and try the workarounds mentioned there. It would be nice, if you could add some system information from your system, where the problem is reproduce able. Hopefully the bug will be fixed soon.
Also have a look at these bugs: bug 10778 bug 13335
And you could also have a look here: http://forum.winehq.org/viewtopic.php?t=4101